New Biosensor Chip Picks Up Heart Signals Remotely

The technology will also use body sensing for gaming, aiding the disabled, helping emergency responders, and switching on the lights

3 min read

1 November 2011—Medical technologists are in hot pursuit of methods for unobtrusively monitoring the body, and video-game-system makers are on the same trail: Nintendo’s Wiimote and Microsoft’s Kinect follow body movements, and products being developed by NeuroSky and Emotiv use physiological signals to control the game.

The kind of sensing NeuroSky and Emotiv are peddling is poised to become even less obtrusive with the introduction of a new technology that detects the voltage change in the body’s muscles and nerves without electrical contact. In October, Plessey Semiconductors of Roborough, England, began shipping samples of its Electric Potential Integrated Circuit (EPIC), which measures minute changes in electric fields. In videos demonstrating the technology, two sensors placed on a person’s chest delivered electrocardiogram (ECG) readings. No big deal, you say? The sensors were placed on top of the subject’s sweater, and in future iterations, the sensors could be integrated into clothes or hospital gurneys so that vital signs could be monitored continuously—without cords, awkward leads, hair-pulling sticky tape, or even the need to remove the patient’s clothes.

Though the technology is being introduced to pick up heart signals, EPIC’s developers say it is also good at sensing the electrical activity of skeletal muscles, including those that control the eyes. Derek Rye, Plessey’s marketing director, says that researchers are working to include this ability in computer interfaces for assisting the disabled; it would give quadriplegics the ability to control a cursor on a computer screen or operate a motorized wheelchair with a series of eye movements. It could also benefit amputees, who often have residual electrical activity in the muscle at the amputation site. Researchers say that EPIC could serve as a noninvasive interface between the nerves and muscles and a prosthesis, allowing it to respond just as a natural limb would.

EPIC will eventually be used in a consumer device, such as a hands-free gaming controller, says Rye. And waving a hand in a specific way in the vicinity of EPIC sensors could switch lights and electronic devices, such as televisions and computers, on or off. "I’m not pretending that at this moment in time EPIC can do what Microsoft’s Kinect can do with visible light and infrared cameras," Rye says. But a pair of EPIC sensors could approximate what the Kinect does if they used a digital signal processor to interpret signals more effectively and further refined their frequency filtering, which would allow a gadget to discriminate between a slow- and a fast-waving hand.

How does it work? Plessey describes EPIC as essentially a very sensitive, contactless digital voltmeter capable of measuring millivolt changes in electric fields. The sensor’s input impedance is tens of gigaohms, so the act of taking a measurement does not throw off the quantity being measured. Also in the secret sauce is filtering technology that ensures the output does not include signals other than the one you’re attempting to pick up. So when you’re trying to do an ECG trace, the readout doesn’t show the results of the muscular movement involved in respiration.

The EPIC’s sensitivity is so great, says Rye, that it can pick up minute changes in electric fields through walls. He envisions that the sensor could be part of a system that would allow a firefighter to tell whether someone is inside a smoke-filled room.

The technology for being able to sense what the body is doing without physical or electrical contact was developed over the past decade by researchers at the University of Sussex, in England. Robert Prance, head of the team that invented EPIC, says it was initially created as a noninvasive noncontact sensor to aid in their own fundamental physics research. The team had been bedeviled by a vexing electric field measurement problem. Because the researchers feared that sensitive equipment would be damaged by electric discharges, they had to use either large laboratory electrometers that needed frequent recalibration or detectors capable of measuring only in increments of hundreds of volts.

The breakthrough, says Prance, was more the result of independent thinking rather than a technical advance. "Getting away from the obsession with measuring DC data was a big step, intellectually as well as technologically," he says. "Often it’s AC info that people want—very often in the form of how it changes with time. ECG, for example, doesn’t require DC information. Once we decided that we were interested in AC, we were able to use different circuit topologies that freed us up from problems such as DC offsets, temperature and time drift, and the inability to move the sensors or the person being measured without recalibrating the system." Just as important, says Prance, was feeding in a stable input bias current that didn’t compromise input impedance.

"I would say that their claims are quite believable," says Christopher J. James, codirector of the Institute of Digital Healthcare at the University of Warwick, in England. James’s work focuses on the development of advanced processing techniques for analyzing the brain’s electromagnetic activity with the eventual aim of producing a brain-computer interface. Speaking about the University of Sussex researchers, he says, "They really know their stuff. And based on their description of the sensors, it makes sense that the switch to AC decouples you from the need to compensate for effects such as the Earth’s magnetic field."

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This CAD Program Can Design New Organisms

Genetic engineers have a powerful new tool to write and edit DNA code

11 min read
A photo showing machinery in a lab

Foundries such as the Edinburgh Genome Foundry assemble fragments of synthetic DNA and send them to labs for testing in cells.

Edinburgh Genome Foundry, University of Edinburgh

In the next decade, medical science may finally advance cures for some of the most complex diseases that plague humanity. Many diseases are caused by mutations in the human genome, which can either be inherited from our parents (such as in cystic fibrosis), or acquired during life, such as most types of cancer. For some of these conditions, medical researchers have identified the exact mutations that lead to disease; but in many more, they're still seeking answers. And without understanding the cause of a problem, it's pretty tough to find a cure.

We believe that a key enabling technology in this quest is a computer-aided design (CAD) program for genome editing, which our organization is launching this week at the Genome Project-write (GP-write) conference.

With this CAD program, medical researchers will be able to quickly design hundreds of different genomes with any combination of mutations and send the genetic code to a company that manufactures strings of DNA. Those fragments of synthesized DNA can then be sent to a foundry for assembly, and finally to a lab where the designed genomes can be tested in cells. Based on how the cells grow, researchers can use the CAD program to iterate with a new batch of redesigned genomes, sharing data for collaborative efforts. Enabling fast redesign of thousands of variants can only be achieved through automation; at that scale, researchers just might identify the combinations of mutations that are causing genetic diseases. This is the first critical R&D step toward finding cures.

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