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Nanoparticle Both Kills Cancer Cells and Helps Image the Killing Process

“Theranostic” nanoparticle is first to allow the fluorescent imaging of a drug inside a cancer cell

2 min read
Nanoparticle Both Kills Cancer Cells and Helps Image the Killing Process
Although real cancer killing nanoparticles look nothing like the fanciful robots pictured here, they're rapidly accumulating new capabilities.
Illustration: Guillermo Lobo/iStockphoto

The therapeutic capabilities of metallic nanoparticles continue to improve, especially for cancer treatment. Along with their growing therapeutic abilities, they are also piling up diagnostic capabilities as well, like their recent use in enabling iPod drug testing.

Now, thanks to researchers from the University of New South Wales in Australia, metallic nanoparticles have been used to both treat cancer and observe the treatment. This latest development is part of the emerging field of so-called “theranostic” nanoparticles in which the nanoparticle is both a therapeutic and a diagnostic tool.

In a first, the Australian researchers, who published their work in the journal ACS Nano ("Using Fluorescence Lifetime Imaging Microscopy to Monitor Theranostic Nanoparticle Uptake and Intracellular Doxorubicin Release"), used a fluorescence imaging technique to see the release of a drug inside lung cancer cells.

“Usually, the drug release is determined using model experiments on the lab bench, but not in the cells,” said Professor Cyrille Boyer from the UNSW School of Chemical Engineering in a press release. “This is significant as it allows us to determine the kinetic movement of drug release in a true biological environment.”

The researchers were able to deliver the drug and watch it enter the cancer cells by using iron oxide nanoparticles that each had a polymer outer shell. The polymer shells were built so that they could attach to the drug doxorubicin (DOX) and then release the DOX in an acidic environment—inside the cancer cell. The iron oxide nanoparticles within the shell exploited the inherent fluorescence of the DOX by acting as contrast agents to make the fluorescence stand out.

Boyer expects that the iron oxide nanoparticles that they have developed will make it possible to adapt drug treatments to individual patients. “This is very important because it shows that bench chemistry is working inside the cells,” says Boyer. “The next step in the research is to move to in-vivo applications.”

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Restoring Hearing With Beams of Light

Gene therapy and optoelectronics could radically upgrade hearing for millions of people

13 min read
A computer graphic shows a gray structure that’s curled like a snail’s shell. A big purple line runs through it. Many clusters of smaller red lines are scattered throughout the curled structure.

Human hearing depends on the cochlea, a snail-shaped structure in the inner ear. A new kind of cochlear implant for people with disabling hearing loss would use beams of light to stimulate the cochlear nerve.

Lakshay Khurana and Daniel Keppeler
Blue

There’s a popular misconception that cochlear implants restore natural hearing. In fact, these marvels of engineering give people a new kind of “electric hearing” that they must learn how to use.

Natural hearing results from vibrations hitting tiny structures called hair cells within the cochlea in the inner ear. A cochlear implant bypasses the damaged or dysfunctional parts of the ear and uses electrodes to directly stimulate the cochlear nerve, which sends signals to the brain. When my hearing-impaired patients have their cochlear implants turned on for the first time, they often report that voices sound flat and robotic and that background noises blur together and drown out voices. Although users can have many sessions with technicians to “tune” and adjust their implants’ settings to make sounds more pleasant and helpful, there’s a limit to what can be achieved with today’s technology.

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