Wrist Sensor Tells You When to Chug a Gatorade

A wrist-worn device with nine tiny needles could monitor electrolyte levels for athletes and soldiers

2 min read
Wrist Sensor Tells You When to Chug a Gatorade
Sandia National Laboratories researcher Ronen Polsky holds a prototype of a microneedle fluidic chip device able to selectively detect and painlessly measure electrolytes in the interstitial fluids that bathe skin cells. Photo: Randy Montoya

human os icon

Anyone who works up a strong sweat (and a "mean mean thirst") has to eventually replace the lost body salts and fluids by chugging sports drinks or taking electrolyte replacement tablets. A new prototype of a wrist-worn sensor could help eliminate the guessing games by monitoring the electrolyte levels of runners, professional athletes and U.S. soldiers at all times.

The wrist-worn device has nine hollow microneedles to suck colorless fluid from just beneath the skin of the wearer's wrist. Luckily for potential users, it's a painless process that avoids sensitive nerves and only samples the interstitial fluid between skin cells. Sandia National Laboratories worked with the University of North Carolina and North Carolina State University to demonstrate how the microneedles could take up tiny amounts of potassium—one type of electrolyte—and pass the potassium into a fluidic cartridge containing electrodes that can measure the electrolyte levels.

"We want to make the device wearable, noninvasive, and with real-time readout to constantly measure things a doctor might normally order for laboratory tests," said Phil Miller, a graduate student at North Carolina State University, in a press release.

The ability to monitor electrolyte levels is crucial because electrolytes play a key role in maintaining normal body chemistry. They also help convey nerve impulses to the heart and other muscles in the body. 

Each needle is just 800 millionths of a meter (microns) long. The nine needles sit above fluidic channels capable of transporting the interstitial fluid to nine electrodes. Individual electrodes can be tailored to selectively detect and measure certain electrolytes such as potassium, sodium, magnesium, calcium and other salts.

Funding for the effort came from Sandia's Laboratory Directed Research and Development program and the U.S. Defense Threat Reduction Agency. Such backing suggests the U.S. military has a strong interest in any personalized health device that can help better monitor soldiers in the field. But the technology also has obvious applications in the civilian world for both professional athletes and ordinary folks heading out to ride their bikes or run.

"This is the future of personalized health care," said Ronen Polsky, a researcher at Sandia National Laboratories in Albuquerque, New Mexico. "These wearable technologies are just starting to come out in different forms. It's inevitable that people will go there."

The same team of researchers has also considered microneedles for other health-monitoring possibilities. For instance, a previous experiment came up with a sensor array capable of using body fluids drawn by microneedles to measure pH, glucose and lactate levels.

Polsky and his colleagues are patenting their current prototype that can analyze different electrolytes while fitting within the palm of a user's hand or on a person's wrist. But a future "sense-respond" device could do much more than just read electrolyte levels—it could also use certain needles to pipe electrolytes into the wearer as needed for replenishing his or her body. That means future athletes or soldiers may not even have to reach for the Gatorade the next time their levels look low.

The Conversation (0)

This CAD Program Can Design New Organisms

Genetic engineers have a powerful new tool to write and edit DNA code

11 min read
A photo showing machinery in a lab

Foundries such as the Edinburgh Genome Foundry assemble fragments of synthetic DNA and send them to labs for testing in cells.

Edinburgh Genome Foundry, University of Edinburgh

In the next decade, medical science may finally advance cures for some of the most complex diseases that plague humanity. Many diseases are caused by mutations in the human genome, which can either be inherited from our parents (such as in cystic fibrosis), or acquired during life, such as most types of cancer. For some of these conditions, medical researchers have identified the exact mutations that lead to disease; but in many more, they're still seeking answers. And without understanding the cause of a problem, it's pretty tough to find a cure.

We believe that a key enabling technology in this quest is a computer-aided design (CAD) program for genome editing, which our organization is launching this week at the Genome Project-write (GP-write) conference.

With this CAD program, medical researchers will be able to quickly design hundreds of different genomes with any combination of mutations and send the genetic code to a company that manufactures strings of DNA. Those fragments of synthesized DNA can then be sent to a foundry for assembly, and finally to a lab where the designed genomes can be tested in cells. Based on how the cells grow, researchers can use the CAD program to iterate with a new batch of redesigned genomes, sharing data for collaborative efforts. Enabling fast redesign of thousands of variants can only be achieved through automation; at that scale, researchers just might identify the combinations of mutations that are causing genetic diseases. This is the first critical R&D step toward finding cures.

Keep Reading ↓ Show less