Brain Stimulation Via Earbuds: Unobtrusive Technology Could Treat a Variety of Diseases

The startup Nēsos emerges from stealth mode with early human trial data on arthritis

3 min read
The Nēsos device
Photo: Nēsos

They look like regular earbuds, but these headphones don’t play music, or produce any kind of sound. Instead, they produce electrical fields designed to treat disease.

By delivering electrical pulses to a nerve in the outer ear, the device hacks into neural circuits in the brain in a way that could regulate inflammation and treat rheumatoid arthritis. 

That’s the hope, anyway, of researchers at the start-up Nēsos, which launched out of stealth mode today. “We’re still at the early stages of development,” says Konstantinos Alataris, co-founder and CEO of the company. “We're developing this as a prescription product and testing it in clinical trials.” 

And arthritis is just the first application that the startup is pursuing. If Nēsos has found an effective way to hack into the brain, the earbuds could help with a range of neurological and psychiatric diseases.

The results of the company’s first in-human study were presented last month at the American College of Rheumatology 2020 meeting. In that study, 30 people with rheumatoid arthritis were instructed to use the earbuds for a few minutes a day, for three months.

By the end of the study, half of the volunteers had improved in a clinically meaningful way. More than half of those patients who benefited showed a 20 percent improvement, a third improved by 50 percent, and a few patients experienced a 70 percent improvement in symptoms.

The Miracle Nerve

Nēsos’s device taps into the power of the vagus nerve: the meandering superhighway of the nervous system that connects the brain to key organs in the body. This nerve has been the subject of a wide range of research. Scientists have tried modulating it to treat all sorts of maladies, including migraine, strokeheart failure, depression, and inflammatory problems such as Crohn’s disease, with varying degrees of success. 

This kind of treatment, called neuromodulation, typically involves surgically implanting a stimulation device with electrodes that directly touch neural fibers. Electrical impulses are then sent to the vagus nerve to change the communication between neurons. 

The company SetPoint Medical, for example, has had some success treating rheumatoid arthritis with an implanted device that stimulates a subset of vagus nerve fibers in the neck. Researchers have found that stimulating those fibers activates cells in the spleen that ultimately block the production of inflammatory molecules called cytokines. The treatment reduces inflammation, and that’s exactly what people with rheumatoid arthritis need.

Nēsos’s device targets the same pathway, except with a completely non-invasive device that fits in the ear like an earbud. And instead of targeting the vagus nerve in the neck, the earbuds, through the auricular branch of the vagus nerve, send electrical impulses to brain regions believed to regulate spleen output and the immune response.  

"Fifty years ago, we thought that the brain and the immune system were independent," says Alataris. "Now we know that they're in constant communication and interaction." 

A Trade-Off

Surgically implanted stimulation devices tend to be more precise than non-invasive devices (such as earbuds) that don’t break the skin and can’t make direct contact with the targeted neural fibers. But surgical neural implants are typically reserved for people who have exhausted most of their treatment options, or are in late stages of disease. A non-invasive device, however, allows Nēsos to try the therapy on people in earlier stages of disease, says Alataris. 

Nēsos is now starting on a larger human study that will compare the effects of the device on people with rheumatoid arthritis and a control group. The company is also testing its technology in people with postpartum depression and migraines. 

Rigorous clinical studies are necessary if the company wants to get regulatory approval as a medical device and claim that its technology treats disease. That kind of data will also differentiate Nēsos’s device from the growing number of stimulating earbud and headphone products on the consumer market. Makers of these devices often claim their devices improve “wellness,” but lack rigorous science to back up such statements.

Nēsos will be backed by data, Alataris says. “As long as the data supports it, we will keep going,” he says. “And so far, the data tells us to keep going.”

The Conversation (0)

This CAD Program Can Design New Organisms

Genetic engineers have a powerful new tool to write and edit DNA code

11 min read
A photo showing machinery in a lab

Foundries such as the Edinburgh Genome Foundry assemble fragments of synthetic DNA and send them to labs for testing in cells.

Edinburgh Genome Foundry, University of Edinburgh

In the next decade, medical science may finally advance cures for some of the most complex diseases that plague humanity. Many diseases are caused by mutations in the human genome, which can either be inherited from our parents (such as in cystic fibrosis), or acquired during life, such as most types of cancer. For some of these conditions, medical researchers have identified the exact mutations that lead to disease; but in many more, they're still seeking answers. And without understanding the cause of a problem, it's pretty tough to find a cure.

We believe that a key enabling technology in this quest is a computer-aided design (CAD) program for genome editing, which our organization is launching this week at the Genome Project-write (GP-write) conference.

With this CAD program, medical researchers will be able to quickly design hundreds of different genomes with any combination of mutations and send the genetic code to a company that manufactures strings of DNA. Those fragments of synthesized DNA can then be sent to a foundry for assembly, and finally to a lab where the designed genomes can be tested in cells. Based on how the cells grow, researchers can use the CAD program to iterate with a new batch of redesigned genomes, sharing data for collaborative efforts. Enabling fast redesign of thousands of variants can only be achieved through automation; at that scale, researchers just might identify the combinations of mutations that are causing genetic diseases. This is the first critical R&D step toward finding cures.

Keep Reading ↓ Show less