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Alzheimer's-Causing Protein Could Be Nanomaterial of the Future

Up till now, the connection most people would make between nanomaterials and Alzheimer’s has always been as a potential treatment for the devastating disease. But now, instead of a nanomaterial treating the disease, researchers at the Chalmers University of Technology in Sweden are taking the protein that causes the disease and making it a nanomaterial.

The protein is known as amyloid, which is a very dense biomaterial that some researchers have been experimenting with for over a decade by combining it with other materials to alter its characteristics. What the Swedish researchers discovered is that if you expose the amyloid protein to multi-photon irradiation you could change the characteristics of the materials that have been attached to amyloid.

The research, which was published in the journal Nature Photonics (“Multiphoton absorption in amyloid protein fibres”),  could lead to optical techniques for detecting and studying amyloid structures with the aim of advancing the treatment of the brain diseases it causes.

Researchers at Chalmers and Wroclaw University of Technology in Poland revealed last month how laser techniques aimed at the amyloid protein could help find a cure for not only Alzheimer’s, but also other brain diseases caused by the amyloid, such as Parkinson’s and Creutzfeldt-Jakob disease (known as Mad Cow disease).

“Nobody has talked about using only light to treat these diseases until now,” says Piotr Hanczyc at Chalmers in a press release. “This is a totally new approach and we believe that this might become a breakthrough in the research of diseases such as Alzheimer’s, Parkinson’s and Creutzfeldt-Jakob disease. We have found a totally new way of discovering these structures using just laser light.”

But beyond a treatment for these brain diseases, the researchers believe that it could have even more far afield applications in photonics an optoelectronics. The researchers believe that the ability to change the characteristics of a material that have been merged with the amyloid just by using multi-photon irradiation opens up some sci-fi capabilities for the material.

One potential application is creating a metamaterial with the amyloid merged with another material. The metamaterial would alter how light is reflected off of it and make it invisible to us.

A less far-off photonic application for the material may be in the development of improved solar cells, according to Hanczyc. But even this seems a bit speculative since the multi-photon tests on the materials tied to amyloids haven’t even performed yet.

Photo: Mats Tiborn/Chalmers University of Technology

Graphene-based Nanoantennas Could Speed Up Wireless Networks

Researchers at the Georgia Institute of Technology say they've demonstrated via computer modeling that nano-antennas made from graphene could enable networks of nanomachines

It’s not clear exactly what kind of nanomachines the researchers are referring to, but a guess is that they are something along the lines of Eric Drexler’s proposal nearly thirty years ago of universal assemblers. I suppose another computer simulation of how nanomachines could be developed is welcome, but it sure would be good to see more physical experiments in developing the little rascals. In any case, I am not sure that making antennas for them has been the main stumbling block preventing them from being built over the last three decades.

Aside from enabling communication between nanomachines, the graphene antennas could be used in mobile phones and Internet-connected laptops to help them communicate faster.

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Graphene Production Combined Into One-Step Method for Wafer-Scale Films

In the first decade of graphene research, the preoccupation was with trying to figure out its properties and what applications it might be suited for. It seems that for the second decade of research—at least at the start—the focus has been on how to better manufacture the wonder material. While the initial research thrust, which expands our understanding of graphene's usefulness, continues, there is an increasing push to find ways to manufacture the material to the specifications required for applications such as electronics.

On the manufacturing front, research seems to be turning to nature for direction. We’ve seen it recently in efforts using “survival of the fittest” crystal growth schemes. And in the latest bit of research out of the National University of Singapore (NUS), researchers who mimicked the way beetles and tree frogs keep their feet attached to submerged leaves achieved, for the first time, both the hoped-for growth and transferability of high-quality graphene onto silicon.

The NUS research, which was published in the journal Nature (“Face-to-face transfer of wafer-scale graphene film”), addressed the fundamental problems of growing large films of graphene through chemical vapor deposition (CVD) on copper and then removing them. While CVD processes yield a high-quality graphene (though, to date, not on the level of that produced by mechanical cleavage of graphite—the so-called “Scotch-tape” method) and promises roll-to-roll production of the material, taking the graphene films off the copper is exceedingly difficult because of the impurities of the copper.

The NUS researchers have dubbed their technique “face-to-face” transfer because the graphene is grown on the copper while the copper sits on top of a silicon substrate. Instead of tearing away the graphene, the copper is etched away while the graphene is lashed to the silicon by bubbles that form capillary bridges; this is the same phenomenon that lets the feet of beetles and frogs adhere to submerged leaves. The trick to achieving the capillary bridges—ensuring that the two layers do not delaminate during the etching away of the copper—was injecting gases into the wafer.

“The direct growth of graphene film on silicon wafer is useful for enabling multiple optoelectronic applications, but current research efforts remain grounded at the proof-of-concept stage,” says Professor Loh Kian Ping, who heads the Department of Chemistry at the NUS Faculty of Science, in a press release. “A transfer method serving this market segment is definitely needed, and has been neglected in the hype for flexible devices.”

The NUS team believes the “face-to-face” transfer method would be useful in batch-processed semiconductor production lines.

Photo: National University of Singapore

Bose-Einstein Condensate Made at Room Temperature for First Time

The quantum mechanical phenomena, known as Bose-Einstein Condensate (BEC), was first demonstrated in 1995 when experiments proved that the septuagenarian theory did in fact exist in the physical world. Of course, to achieve the phenomena a state of near absolute zero (-273 Celsius, -459 Fahrenheit) had to be created.

Now researchers at IBM’s Binnig and Rohrer Nano Center have been able to achieve the BEC at room temperature using a specially developed polymer, a laser, and some mirrors.

IBM believes that this experiment could potentially be used in the development of novel optoelectronic devices, including energy-efficient lasers and ultra-fast optical switches. One application for BEC is for the building of so-called atom lasers, which could have applications ranging from atomic-scale lithography to measurement and detection of gravitational fields.

Okay, you’re probably asking what is a Bose-Einstein Condensate? First, the history. Satyendra Nath Bose and Albert Einstein theorized that this state of matter existed in the mid-1920s when the two scientists were formulating their predictions on the characteristics of elementary particles, known as Bose-Einstein statistics.

The actual state of matter for the BEC occurs when a dilute gas of bosons—a fundamental particle—has been cooled to near absolute zero so that the bosons occupy the lowest quantum state. It has alternatively been described as “as a superatom, where all the atoms share the same quantum mechanical state.”

Until this latest research, which was published in the journal Nature Materials (“Room-temperature Bose–Einstein condensation of cavity exciton–polaritons in a polymer”), the only way to get the BEC was freezing bosons.

For the first time, the IBM team achieved it at room temperature by placing a thin polymer film—only 35 nanometers thick—between two mirrors and then shining a laser into the configuration. The bosonic particles are created as the light travels through the polymer film and bounces back and forth between the two mirrors.

While this BEC state of matter only lasts for a few picoseconds (trillionths of a second), the IBM researchers believe that it exists long enough to create a source of laser-like light or an optical switch that could be used in optical interconnects.

“That BEC would be possible using a polymer film instead of the usual ultra-pure crystals defied our expectations,” said Dr. Thilo Stöferle, a physicist, at IBM Research, in a press release. “It’s really a beautiful example of quantum mechanics where one can directly see the quantum world on a macroscopic scale.”

Now that the researchers have managed to trigger the effect, they are now looking to gain more control over it. In the process they will be evaluating how the effect could best be exploited for a range of applications. One interesting application that will be examined is using the BEC in analog quantum simulations for such macroscopic quantum phenomena as superconductivity, which is extremely difficult to model with today’s simulation approaches.

Illustration: IBM Research

Dueling Nanowire Lasers Promise Big Changes to Optoelectronics

There appears to be a crush of nanowires laser research. About two weeks ago researchers from the Australian National University (ANU) announced what they claimed to be the first room-temperature lasers made from semiconductor nanowires. And now researchers at the Technische Universitaet Muenchen (TUM) say they too have built semiconductor nanowires that act as lasers at room temperatures.

With the ANU paper being submitted to Nature Photonics (“Optically pumped room-temperature GaAs nanowire lasers”) on 8 July  and then the TUM paper being submitted to Nature Communications one month later (“Lasing from individual GaAs-AlGaAs core-shell nanowires up to room temperature’), the two research projects could understandably both claim to be the first.

But beyond claims of primacy, it appears that the breakthroughs could open up a new avenue for speeding up a range of applications, such as on-chip optical interconnects and integrated optoelectronics for fiber-optic communications.

While these III-V semiconductor nanowires still fall short of the holy grail of getting silicon to act as a laser (though researchers at the University of Pennsylvania did succeed earlier this year in getting a silicon nanowire to emit light through manipulating it with plasmonics), both the ANU and TUM teams are claiming that their nanowires can be grown on silicon. And because of that, they believe the nanowire lasers will win a place in future integrated photonics and optoelectronics.

"The wires and lasers will lead to much faster, much lighter computers because light travels faster than electrons, allowing us to process data much faster," explained Dhruv Saxena from the ANU Research School of Physics & Engineering, in a press release last month.

The leader of the TUM research, Prof. Jonathan Finley, director of TUM's Walter Schottky Institute, more or less echoed this sentiment in a press release this week.

"Nanowire lasers could represent the next step in the development of smaller, faster, more energy-efficient sources of light," said Finley, in the statement.

Both the ANU and TUM teams do face some obstacles that need to be overcome. Both teams acknowledge that the laser emission from the nanowires was simulated by light. To really get to the point of practical applications electrically injected devices, in which the lasers are powered by electricity, will likely be required.

Image: WSI/TU

Viruses Build Piezoelectric Nanogenerator Through Self Assembly

Nanotechnology has opened up the possibility of building things like nature does: on the nanoscale. As such, biomimicry has been a guiding principle of nanomanufacturing.

But unlike natural processes, artificial synthesis of nanoscale structures has often required toxic and expensive conditions. Now researchers at the Korea Advanced Institute of Science and Technology (KAIST) say they've developed a synthesis process that can be done in a more natural way without the costly and extreme environments previously required.

What the researchers came up with uses a harmless, man-made virus, known as the M13 viral gene. The researchers modified it so that it acted as a template for a piezoelectric material, barium titanate (BaTiO3).

The research, which was published in the journal ACS Nano (“Virus-Directed Design of a Flexible BaTiO3 Nanogenerator”), demonstrated that they could build a high-performance, flexible nanogenerator from the piezoelectric material using the M13 viral gene as template for guiding self-assembly of the device.

"This is the first time to introduce a bio-templated inorganic piezoelectric material to a self-powered energy harvesting system, which can be realized through eco-friendly and efficient material syntheses," said Professor Keon Jae Lee from the Department of Material Science and Engineering at KAIST in a press release.

But, of course, using man-made viruses to guide the self-assembly of devices has long been the purview of Angela Belcher at MIT for over a decade. Nonetheless, we can’t quibble that this marks the first time that a virus template was used to create a nanogenerator. And it has a pretty respectable electrical output performance, claimed in the research paper to be about 300 nanoampere and 6 volts.

In fact, the real breakthrough of the research may be that the biosynthetic method that the KAIST researchers developed could open up new possibilities in bio-inspired self-assembly for applications ranging from thermoelectrics to biofuel cells.

Nanorods Enable Regeneration of Damaged or Severed Materials

Sometimes when you combine nanotechnology with biomimetic capabilities you get the somewhat mundane, such as the water-repellant properties of a lotus flower. But other times, you get superhero capabilities, like being able to climb a wall like Spiderman.

Now we have a biomimetic capability enabled by nanotechnology that seems to be really something out of sci-fi—regenerating damaged or severed sections of material, just as some amphibians can grow back amputated limbs.

Although the technology has only been demonstrated in a computer model, it marks the first time that bulk sections of severed materials have been shown to be capable of regenerating.

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Nanomedicines Will Be Big Once They Emerge From Regulatory Troubles

There seems to be a nagging sense among some observers of nanotech—most especially government entities charged with evaluating its progress—that so far it just hasn’t delivered on its promise.

So too seems to be the sentiment with a conference held last week at The New York Academy of Sciences entitled “Nanomedicines: Addressing the Scientific and Regulatory Gap” in which the conference title implies that nanomedicine commercialization has fallen somewhat short of expectations thanks in part to regulatory limitations and uncertainty.

I spoke to one of the conferences organizers and speakers, Dr. Raj Bawa, patent agent at Bawa Biotech LLC, a biotechnology consultancy and patent law firm (he's also an adjunct professor at Rensselaer Polytechnic Institute) on what the limitations were and what the potential fixes might be.

Surprisingly to me, Bawa believes that the issue of definitions for nanotechnology still plays a critical role in hindering its development, at least for nanomedicines and possibly for the entire field of nanotechnology.

Bawa is distressed that many U.S. regulatory bodies and agencies, primarily the Patent & Trademark Office (PTO) and the Food and Drug Administration (FDA), have labored under the strict size guideline laid out by the original definition proposed by the National Nanotechnology Initiative. That guideline does not consider anything to be nanotech unless one or more of its dimensions are under 100nm. Bawa points out that while this somewhat arbitrary size guideline makes sense for advanced materials in which often the novel electrical, conductive or optical properties of a material don’t reveal themselves until they get below 100 nm, it makes little or no sense for nanomedicines, in which the active ingredient that completely changes the drug’s efficacy, safety profile, solubility, or bioavailability can be 1000 nm across or more.

However, Bawa sees signs of hope, especially from the FDA, which in the last couple of years has issued draft guidances related to nanotechnology that he believes represent moves in the right direction.  

“The FDA seems to have said essentially that their investigation of nanotechnology and its regulations needs to be science-based rather than policy based. That’s a positive development for the pharmaceutical industry going forward as they explore nanomedicines as a viable option to some of their formulation woes,” says Bawa.

But Bawa still has reservations about the way the US Patent and Trademark Office is examining and classifying nanopatents. He even suggests a possible open-source licensing solution in some cases where basic nanotechnology patents on upstream "building block" technologies may cause "patent thickets"

The reason nanomedicines are coming into sharp focus is the state of the pharmaceutical industry. We are in the post-blockbuster world now, according to Bawa, and nanomaterials and reformulations via nanotech have offered a way to recoup some of the huge R&D investments that have been made in drugs that failed along the way in the FDA regulatory process.

“Around forty percent of new molecular entities fail during R&D because they are not water soluble,” explains Bawa. “It’s estimated that over $135 billion could be produced in new drugs by tweaking these abandoned entities if this critical solubility issue can be resolved, possibility employing nanoscience.”

With that kind of potential revenue, it is odd that big pharma has not attempted to exploit nanotech more than they have. It would seem Elan Drug Technologies is one of the few examples of a pharma company that has used nanotechnology to create drug products. Its milling technique, called NanoCrystal,  breaks down drug crystal sizes to less than 2000 nanometers.

The company has launched five licensed products using the NanoCrystal technology and achieved sales of nearly $2 billion.

Bawa believes that other big pharma companies are working in this area as well but just haven’t yet engineered the right formulations. But he expects that they will come as more meaningful nano-governance takes shape.

Illustration: iStockphoto

Could Tin be the Two-Dimensional Material of the Future?

For the better part of a decade, researchers have been theorizing and calculating about a mysterious new class of materials called topological insulators. In computer models, scientists have been able to reveal that these topological insulators possess the odd property of insulating on the inside and conducting on the outside. It was even demonstrated last year that topological insulators could be produced from heavy metals like uranium and plutonium that could work at room temperature.

Now researchers at U.S. Department of Energy’s (DOE) SLAC National Accelerator Laboratory and Stanford University have simulated what would happen if you whittled a topological insulator down to a single atomic layer—a two-dimensional material like graphene. The result is that the edges of the material become conductors and rest behaves as an insulator.

The researchers have dubbed their new material “Stanene”, which is the combining of the Latin word for tin (stannum) with the suffix used in graphene. They believe that it could be a “wonder material” every bit as fascinating as its carbon cousin, graphene. Initial calculations indicate that it could be the world’s first material to conduct electricity with 100 percent efficiency at the temperatures that computer chips operate.

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Nanoparticles Enable Novel Loudspeaker Design

While technological developments in personal computing always seem to be eagerly received, it seems that developments in our personal entertainment—like TVs and stereos—get us most excited.

Along these lines, there is now a completely new way to build loudspeakers thanks in large part to nanoparticles. Researchers at Sweden’s KTH Royal Institute of Technology have found a way to eliminate the need for a permanent magnet in stereo speakers by adding metallic nanoparticles to a speaker's membrane.

“This is, to our knowledge, the first reported magnetic speaker membrane,” said Richard Olsson, a KTH researcher, in a press release.

The design of the speaker, which is detailed in the journal of the Royal Society of Chemistry (“Cellulose nanofibers decorated with magnetic nanoparticles--synthesis, structure and use in magnetized high toughness membranes for a prototype loudspeaker”) employs cellulose nanofibers that have had ferrite nanoparticles dispersed evenly throughout the membrane.

The result is a speaker that does not need a permanent magnet to drive the membrane and yet produces a sound quality the researchers argue is as good as, if not better than, traditional speaker designs because of the even distribution of forces within the membrane.

In traditional speaker designs, a voice coil is wrapped around a permanent magnet. The voice coil drives the speaker cone’s movements, which produces the sounds that we hear.

In the speaker design resulting from this latest advance, there is still a voice coil but it is obviously not wrapped around a permanent magnet nor is it directly attached to the cone. Instead, sound is produced solely by the movement of air.

This isn't the first time that nanotechnology has been offered as a possible solution to loudspeaker design.  Five years ago, researchers in China demonstrated how carbon nanotubes could be used to create a transparent loudspeaker film. I have not heard whether anything ultimately ever came of that research.

But if KTH's new speaker technology doesn’t get off the ground, the researchers believe that it has alternative applications in sound cancellation and in one of our other favorite technologies: the automobile.

“We want to look at applications for the material that are driven by magnetic fields. It may, for example, be a form of active damping for cars and trains,” says Olsson in the press release.

Photo: Richard Anderssson



IEEE Spectrum’s nanotechnology blog, featuring news and analysis about the development, applications, and future of science and technology at the nanoscale.

Dexter Johnson
Madrid, Spain
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