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Even More Cooperation is Needed in Nanotoxicology Research

I just saw the latest press release from the International Council on Nanotechnology (ICON) based at Rice University.

The announcement details the publishing of findings from two workshops held in January and June of 2007. The press release contains realistic comments from Dr. Vicki Colvin, executive director of ICON and professor of chemistry and chemical engineering at Rice University, that will likely send shivers up the spines of outraged environmental activists such as, â''Our â''grand challengeâ'' â'' producing computational models that predict interactions of engineered nanoparticles with organisms â'' will take some time, perhaps 10 years.â''

But the press release is also peppered with terms like: international workshops, unprecedented international collaboration, the diversity of participants, and international scope.

I have gone through the site to see the list of the 70 representatives to get a sense of this international scope, and I couldnâ''t seem to navigate to it. The best I could find was the Steering Committee.

From this list I could see they tried to hit upon the major targets, albeit it from a slightly more US-centric perspective than all the â''internationalâ'' talk may lead you to believe.

Although the â''Linksâ'' page brings you to all the other international working groups looking at the toxicology of nanoparticles, it isnâ''t clear to me, at least through the website, what sort of cooperative arrangements they have with these other groups.

While it is good to see that everyone is trying to take some role in tackling this issue, it would be preferable to see an even higher level of cooperation and coordination among all these groups. Just off the top of my head, I know there is Organization for Economic Co-operation and Development (OECD), the International Organization for Standardization (ISO), and the American Society for Testing and Materials International (ASTM International) all trying to be universal and comprehensive in their approach to figuring out the EHS issues of nanoparticles.

This seems all a bit fragmented to me. Maybe someone can enlighten me on how all these groups are working in coordinated fashion and there is no unnecessary overalap in their work, so that we can arrive at some more conclusive data on the toxicology of nanoparticles.

More cool stuff from the Xerox Palo Alto Research Center

Yesterday I blogged about a few of the cool innovations presented by Xerox researchers at a show-and-tell for the press held Monday and Tuesday at the Xerox Palo Alto Research Center (Parc). I have to confess, when I first saw my schedule (each journalist went through the demos in a slightly different order, so we didnâ''t crowd together), I suppressed a groan. My morning demos were mostly projects involving document handling, technology targeted at big business applications and not something I thought would be at all interesting.

But I was wrong. Hereâ''s what the future of documents looks like:

Hybrid categorization. Not a great name, maybe the marketing folks will come up with something better when this gets out of the laboratory, but something Iâ''d like to use right now. The idea is that categorization software looks at both images and text around the images to figure out what the document is about. In an office environment, the software could automatically tag and file scanned documents it identifies as particular types of documents, like specific forms. Thatâ''s not what got me. But the researchers demoâ''d their software processing a set of vacation photos. It tagged one photo as â''view, mountain, city,â'' then found similar photos online. By looking at the narratives around those similar photos, it went on to tag the photos Cuzco and Peru. It then distributed that photo and other ones from same trip into a blog entry, placing them appropriately near related text (at the beach, that night, an incredible sunset). Wow. If I could upload my photos to an online service, get them all tagged, and then zapped off to a personal blog, well, that would go a long way towards dealing with the gigabytes full of unlabeled image files sitting on my hard drive. Xerox is currently focused on developing the software as a business package; I think they could spin it out as a Web 2.0 company right now.

The seamless document viewer. A little better name, this Java-based technology is being developed at the FX Palo Alto Laboratory,

a research group owned by the joint venture Fuji Xerox, located just down the road from Xerox Parc. The software is intended to make viewing large documents on small smart-phone screens a lot easier with intelligent zoom (it zooms out to display sections of documents with photos, zooms in on text youâ''re trying to read, tags sections to let you browse through by keyword, and zones and numbers the document to let you select regions with the phone keypad). It did seem easier to navigate a document, though I still canâ''t see me doing much reading on a small phone screen.

Document Product Visualization and Digital Customized Packaging. These names, these names. If youâ''ve got better ideas, please comment below and Iâ''ll forward your suggestions to Xerox. Anyway, the idea is great; itâ''s layout software that lets you fold the document onscreen, to make a brochure, or a box, or complicated 3-D object. Having tried to do theater programs and tri-fold invites with standard layout software, printing countless test versions and finding out that I just didnâ''t position things correctly, I do need this product! Again, Xerox is thinking of marketing it to large businesses or print shops that do custom printing, Iâ''m thinking thereâ''s room for a â''liteâ'' version for the consumer market. The video above demonstrates a greeting card designed using the software.

Solid ink. This isnâ''t a new technology, it came out of Tektronix in the 80s and was IMG_1945.JPG

acquired by Xerox; the novelty being demonstrated this week was a new, smaller, print head that will allow solid ink to be used in more diverse printers. And the message these days is a little new; when Tektronix first brought out the technology it was all about the amazing color; these days, itâ''s about the environmentâ''thereâ''s no ink cartridge to dispose of, the block of ink simply melts away. The company says the process generates 90 percent less waste (thereâ''s still a little packaging around the ink for shipping it, but not much). Thatâ''d be a lot less trips to the recycling center for me.

April Figures Confirm Sharp Drop in Gas Guzzler Sales

Data released yesterday, May 1, confirm earlier indications that sky-high gasoline prices are finally beginning to have a distinct impact on consumer behavior. Total U.S. auto sales in April were at their lowest level in 15 years, with sales of SUVs down drastically but subcompacts like Chevroletâ''s Malibu up 43 percent and Fordâ''s Focus up 32 percent. Sales of Toyotaâ''s hybrid, the Prius, climbed 54 percentâ''the biggest increase among the 15 most popular vehicles highlighted by The New York Times.

The U.S. big three manufacturers all registered double-digit sales declines, while Honda, Nissan, and Toyota came close to holding sales flat.

Inside Xerox Parc 2008

Things have changed at the Xerox Palo Alto Research Center. Gone are the beanbag chairs that furnished the conference room back in the 70s; gone are the researchers that created the graphical user interface, the Ethernet, the laser printer, and other computing innovations we take for granted today. But these famous halls of innovation are not just populated with ghosts from a glorious past, though they did bring back memories; my colleague Paul Wallich and I were among the first journalists to write Parcâ''s story in the early 80s. There is some pretty cool stuff going on right now.

Xerox opened Parcâ''s doors to journalists on Monday and Tuesday this week and brought its researchersâ''and those of sibling research centers, like Fuji Xeroxâ''s FX Palo Alto Laboratory, Xerox Research Centre Europe, and Israelâ''s XMPIEâ''out for show and tell. Some were demonstrating products just reaching the marketplace; others earlier stage research that could become business or consumer products some day. Some of my favorites:

Erasable paper. Like most people, my office is anything but paperless. I print out interview notes, emails, web pages, and countless rough drafts, often needing the documents for just a few hours before tossing the pages into the recycling bin. IMG_1951.JPG

Unfortunately, toggling back and forth between all these documents on the screen just doesnâ''t work. So the idea of completely reusable paper definitely appealed to me. Parcâ''s reusable paper doesnâ''t even need ink. Instead, the paper is chemically treatedâ''but feels just like ordinary printer paperâ''to be sensitive to a specific wavelength of light. The printer simply writes the image in light. The image starts to fade in several hours, and is completely gone in 24; the photo shows the image after several hours of fading and as just printed from a high-speed printer; standard-speed printers will generate darker images. Researchers say that cost of the paper will be three to five times the cost of normal printer paper; the printer itself will cost several hundred dollars, and will be intended as a second printer for homes and offices. The prototype paper is yellow, not because of the chemical coating, but to distinguish it from ordinary paper and prevent users from accidentally printing archival documents in disappearing â''inkâ''.

An adaptation of ink-jet printing intended to replace screen printing of conductive grid-lines for silicon solar cells. Researchers say the change, which makes grid lines

tall and fat instead of thin and wide, improves solar cell efficiency by six percent. Xerox Parc plans to spin out a company, tentatively name Sunlyne, later this year to commercialize the technology.

A water purification system that evolved from research done in manipulating fine particles for laser printing. This purely mechanical system shifts particles to one part of a stream of water, and then splits the stream into two paths, one for clean water, one for dirty water. Researchers expect that, in a couple of years, municipal water treatment plants will be able to use the technology to process significantly more water with less chemicals and without increasing the size of the treatment plant.

IMG_1948.JPGA medical diagnosis technique, also coming out of laser printing, which can find cancer cells in a blood sample much more effectively than current technology. The researchers expect to apply the technique, which uses a scanning laser and a fiber optic bundle to detect fluorescence from tagged cells, to prenatal diagnostics, eventually replacing the invasive amniocentesis with a simple maternal blood test.

More tomorrow.

Working on the Nanoscale Leads to Solving of 37-year-old Electronics Mystery

The latest edition of Spectrum has an absolutely thrilling article on how a 37-year-old postulation of a hidden â''fourth elementâ'' of fundamental electronic components has been found: the memory resistor, or the memristor.

It turns out the memristor was hiding in plain sight, so to speak, and would have gone on being only a mathematical postulation, if Stanley Williams and his team at HP had not been working on molecular electronics. Without working with materials and devices on the nanometer scale, the memresistance effect is just simply overwhelmed by other effects, and without any need to make use of its effects, memresistance could stay hidden for nearly forty years within the electrical characteristics of certain nanoscale devices.

The result of this discovery is that memristor devices could enable non-volatile RAM and neural networks. The article describes Williams as a â''kid in a candy storeâ'', you will feel like one to after reading the article.

The men behind memristance

mem.jpg

PHOTO: R. STANLEY WILLIAMS

The memristor is all over the news today. The fourth circuit element discovered at last!

I can't overstate what a big deal this is. My editor forwarded me the press release with a note asking if I thought it was a really late April Fool's joke.

Usually our reporting takes the form of "smallest chip created!" or "farthest constellation photographed!" or "most powerful microscope invented!" -- That's about as enthusiastic as things get in this corner of the journalism world. (Not that there's anything wrong with smaller transistors.) But let's face it, it's the same headline this year, next year, and the year after that. But how often do we get to write about something completely new?

I was excited: but Stan Williams, the HP scientist who discovered the new element, was practically jumping up and down when I talked to him. "It was pretty euphoric," he told me. (I don't hear that word a lot.)

This ended up being a genuine mystery story, complete with hidden treasures and forgotten maps (that map being the 1971 paper by Leon Chua that foretold the existence of a fourth circuit element). Williams said the memristor has been sitting there waiting for someone to discover it for over 100 years. "There was no reason for people even during Maxwell's time not to have come up with a memristor," he said. "It took Leon to figure out that there was something that should be there. And then it took another 40 years until I was able to figure out what it was and how to make it."

Chua was excited too (and by the way, Chua is a big, big deal in the engineering community). He told me electronics engineering text books will need a rewrite. "I'm very happy," he told me. "This is a breakthrough that will set a paradigm shift!"

Chua was so excited that he kept mixing his metaphors-- every time he talked about the memristance phenomena that people had been seeing in their nanoscale devices, he would tell me that the nano community had been "barking up the wrong horse."

I will say one thing, though: memristor? Really? It took me three days to stop saying memresistor, a full week to stop typing memresistor, and all the while my editor kept changing memristor to memresistor in the story.

It's still early in the game-- it's not in the textbooks yet! Is there still time to change the name?

Purdue supercomputer to be installed in just one day

Purdue plans to assemble what will be the world's 40th ranked supercomputer in just one day, 5 May to be exact.

I worry, not that they won't make their deadline, but that, in the rush, one of the 200 volunteer assemblers will become inextricably entangled in the interconnects in such a way that for Purdue to meet its deadline, he or she will have to spend eternity (or at least the night) inside the supercomputer.

Don't laugh. It happened to Mike Mulligan and his steam shovel. Except Mike was trying to dig the cellar of Popperville's new town hall in just one day, not assemble a supercomputer. If you're not familiar with the story, Mike and Maryanne (the steam shovel) won't get paid unless he digs the cellar in one day, a feat that would take 100 men a week to do. They dig it in such a rush, they forget to leave a way out for Maryanne. The solution is to make Maryanne the town hall's furnace and Mike the town hall's janitor. So they just build the town hall right over the pair of them. Mike gets an easy job and Maryanne keeps puffing steam. All's well.

Maybe the interconnect-entangled student could get a tech-support gig.

From the press release:

May 1, 2008

Purdue to install Big Tenâ''s biggest campus computer in just a day

WEST LAFAYETTE, Ind. - The largest supercomputer on a Big Ten campus will be installed at Purdue in a single-day, electronic "barn-raising.â''

More than 200 employees will gather May 5 to help build the massive machine, which will be about the size of a semitrailer when installed. It will be the largest Big Ten supercomputer that is not part of a national center.

Purdueâ''s computer is being built in a single day to keep the university's science and engineering researchers from facing a lengthy downtime, says Gerry McCartney, vice president for information technology and chief information officer.

"Our staff thought we were insane when we challenged them to build such a big computer in a single day," McCartney says. "But now thereâ''s real excitement to be a part of this."

To generate interest on campus, the organizers created a spoof movie trailer called â''Installation Day,â'' which is a take off of the movie â''Independence Day.â'' The video can be seen on YouTube at http://www.youtube.com/watch?v=wVzThRN4QJI

Supercomputers are ranked by their performance in running a complex benchmarking system. The results of the tests are published twice each year at http://www.top500.org. Purdueâ''s new supercomputer would rank in the top 40 of the current Top 500 list, which was published in Nov. 2007.

Will NIST's Proto-Prototype Nano Assembler Lead to Prototypical Mechanosynthesis?

Recent research at the National Institute of Standards and Technology (NIST) using MEMS devices to move atoms instead of employing atomic force microscopes (AFMs) as mentioned in the article has opened up the possibility for a new tool in nanomanipulation. Radical nanotechnology proponents are heralding it as an enabling technology for molecular manufacturing.

One of the knocks on STM and AFM nanomanipulation, at least in terms of it being â''protypical mechanosynthesisâ'', is that the manipulation does not involve â''reactive (and re-chargeable) molecular toolsâ''.

Jason Gorman of the Intelligent Systems Division at NIST, who will publish the research in a forthcoming issue of the International Journal of Nanomanufacturing, has taken a different approach to the typical use of AFMs for nanomanipulation and the result could pass the "reactive and rechargeable molecular tool" test.

Gorman and his colleagues at NIST have developed a system that is described in the article announcing the research as â''four MEMS devices positioned around a centrally located port on a chip into which the starting materials can be placed. Each nanomanipulator is composed of a positioning mechanism with an attached nanoprobe. By simultaneously controlling the position of each of these nanoprobes, the team can use them to cooperatively assemble a complex structure on a very small scale.â''

Whether or not the MEMs-device system fits into a definition of mechanosynthesis or not, it appears that the technology could overcome some of the difficulties faced with top-down nanomanipulation using AFMs, such as nanoparticles sticking together during manipulation making them impossible to be lifted from the substrate.

The result could be nanoassembly systems that could be made for around $400 per chip, making them thousands of times cheaper than macro-scale systems such as the AFM.

Trust in Integrated Circuits

DARPA's Trust in Integrated Circuits program has been hitting the news on and off over the past few months, ever since they released the details of the program back in December. The program, which aims to verify the integrity of the electronics that will underpin critical military hardware like the F-35 Joint Strike Fighter, could give the military, and defense contractors, a guaranteed way to check if their chips have been compromised.

If the program pans out and produces a real way to verify microprocessors, itâ''ll be interesting to see how a Trusted chip imprimatur will play with the Trusted Foundries program. (Trusted Foundries were set up to counter what the DoD perceives as a rising threat to defense microelectronics posed by the offshoring bleed in the semiconductor industry.) Every article about the DARPA program (including mine) maintains that there is no conflict between a chip verification method and the Trusted Foundries program.

Will a DARPA Good housekeeping seal of approval become a standard last step in the trusted foundry procedure? Will one of these Trusted Entities get knocked out of the ring, or will the government integrate them into one oversight body?

All of this brings me to the point: On April 9, Northrop Grumman announced that its Advanced Technology Laboratories (ATL) semiconductor plant, in Maryland, had just achieved Trusted Foundry status. In fact, their accreditation is Category 1A which is, as you'd expect, the highest level that can be awarded to a foundry. A scant two weeks later, they won multiple contracts for the F-22 Raptor. Northrop gets $252 million to design and manufacture the F-22â''s communications, navigation and identification subsystems. Thatâ''s a lot of chips.

The programs themselves are not in conflict. The first question might be: if you have a way to â''ensureâ'' that a chip is pure, why do you need your own (more expensive) stateside fabs? Because you don't want someone reverse engineering your most mission critical circuits, like the stuff that goes into an F-35. Thatâ''s a no-brainer.

But there are an awful lot of cooks working on the soup.

Trusted Foundries by definition are onshore, and they go through an accreditation process that can only be called grueling; verifying a facility can take months to years.

Then you have your Trusted Designers, like Sandia National Laboratoriesâ'' microelectronics center. These guys design the chips, but their Paleolithic .35 micron fab is ill-equipped to produce chips for anything anyone needs these days, so they send the designs to a trusted foundry to produce.

But some people don't even agree that they're safe once they've hit the foundry. "Even domestically there may be problems," HRLâ''s Charles Henry Field told me (HRL is one of the official TAPO trusted foundries). You need trust all the way through the supply chain. Malicious tampering could happen all the way down the chainâ''what about the delivery truck?"

So what exactly will IARPA do?

When I interviewed Lisa Porter about the kinds of projects the Intelligence Advanced Research Projects Activity (the web site isn't quite ready for prime time, but should be up within a week) would take on, she would not get specific, because most of those projects will be classified. But Carl Landwehr, a program leader at the National Security Agency, elaborated on what projects are now being considered at IARPA. These include revamping the infrastructure of the internet to counter threats like the Storm worm, and addressing fundamental software flaws that prevent true cybersecurity.

Cybersecurity is becoming a major concern, and doubly so for the intelligence community. For intelligence analysts, assurance that their information is solidly based and not sabotaged in any way is extremely important. Some IARPA projects will focus on techniques that will stop the multitudes of attacks on the flaws built into commercial software. Itâ''s no secret that that commercial software often ends up in military (and other classified) environments. Security is not the primary consideration during the cycle of that softwareâ''s design: it certainly does not take precedence over time to market and features. â''The flaws in software implementations are often exploited by attackers,â'' Landwehr says. That doesnâ''t mean exploitation is easy, but one of IARPAâ''s priorities, he says, will likely be to look into techniques to thwart these attacks.

Landwehr also points to Storm as a consequence of an existing infrastructure that provides weak accountability. "There's a lot of bleeding out there," he says. "Network attacks have become a commercially productive activity for a lot of people who are trying to make money. That's an urgent concern. With the current infrastructure, itâ''s very difficult to trace back attacks, or even to tell when youâ''re being attacked. Packet streams can come at you from anywhere.â'' IARPA is interested in funding long-term research that would make it more difficult for a Storm type of threat to occur. "We could spend a lot of research money on trying deal with current attacks and never really solve the problem," he says. "But if we spend some effort looking further out, we might change the infrastructure so that these attacks just couldnâ''t happen."

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