Nanoparticle Carrying Bee Venom Could Prevent HIV Infection and Cure It
Nanoparticles are proving themselves effective carriers, delivering therapies within the human body.
Last year, nanoparticles carrying biological components proved effective as anti-viral treatments for Hepatitis C. And some years back, research also demonstrated that attaching short-interfering RNA (siRNA) molecules to a biodegradable polymer nanoparticle was effective in the treatment of sexually transmitted diseases, like the human immunodeficiency virus (HIV).
Now researchers at the Washington University in St. Louis have attacked HIV more directly. They have shown that a nanoparticle carrying bee venom effectively destroys HIV while leaving surrounding cells unharmed.
The research, which was published in the journal Antiviral Therapy ("Cytolytic nanoparticles attenuate HIV-1 infectivity"), employed a nanoparticle that had previously been abandoned when it proved ineffective for delivering oxygen to blood cells. But in its new role, carrying the toxin melittin, a poison found in bee venom, it is extremely effective at breaking down the essential structure of HIV.
“We are attacking an inherent physical property of HIV,” says Joshua L. Hood, MD, PhD, a research instructor in medicine at Washington University in a press release. “Theoretically, there isn’t any way for the virus to adapt to that. The virus has to have a protective coat, a double-layered membrane that covers the virus.”