So far, besides our glucose monitor, we’ve been able to batch-fabricate a few other nanoscale biosensors that respond to a target molecule with an electrical signal; we’ve also made several microscale components, including single-crystal silicon transistors, radio chips, antennas, diffusion resistors, LEDs, and silicon photodetectors. We’ve constructed all the micrometer-scale metal interconnects necessary to form a circuit on a contact lens. We’ve also shown that these microcomponents can be integrated through a self-assembly process onto other unconventional substrates, such as thin, flexible transparent plastics or glass. We’ve fabricated prototype lenses with an LED, a small radio chip, and an antenna, and we’ve transmitted energy to the lens wirelessly, lighting the LED. To demonstrate that the lenses can be safe, we encapsulated them in a biocompatible polymer and successfully tested them in trials with live rabbits.

 

Photos: University of Washington

Second Sight:

In recent trials, rabbits wore lenses containing metal circuit structures for 20 minutes at a time with no adverse effects.

 

Seeing the light—LED light—is a reasonable accomplishment. But seeing something useful through the lens is clearly the ultimate goal. Fortunately, the human eye is an extremely sensitive photodetector. At high noon on a cloudless day, lots of light streams through your pupil, and the world appears bright indeed. But the eye doesn’t need all that optical power—it can perceive images with only a few microwatts of optical power passing through its lens. An LCD computer screen is similarly wasteful. It sends out a lot of photons, but only a small fraction of them enter your eye and hit the retina to form an image. But when the display is directly over your cornea, every photon generated by the display helps form the image.

The beauty of this approach is obvious: With the light coming from a lens on your pupil rather than from an external source, you need much less power to form an image. But how to get light from a lens? We’ve considered two basic approaches. One option is to build into the lens a display based on an array of LED pixels; we call this an active display. An alternative is to use passive pixels that merely modulate incoming light rather than producing their own. Basically, they construct an image by changing their color and transparency in reaction to a light source. (They’re similar to LCDs, in which tiny liquid-crystal ”shutters” block or transmit white light through a red, green, or blue filter.) For passive pixels on a functional contact lens, the light source would be the environment. The colors wouldn’t be as precise as with a white-backlit LCD, but the images could be quite sharp and finely resolved.

We’ve mainly pursued the active approach and have produced lenses that can accommodate an 8-by-8 array of LEDs. For now, active pixels are easier to attach to lenses. But using passive pixels would significantly reduce the contact’s overall power needs—if we can figure out how to make the pixels smaller, higher in contrast, and capable of reacting quickly to external signals.

By now you’re probably wondering how a person wearing one of our contact lenses would be able to focus on an image generated on the surface of the eye. After all, a normal and healthy eye cannot focus on objects that are fewer than 10 centimeters from the corneal surface. The LEDs by themselves merely produce a fuzzy splotch of color in the wearer’s field of vision. Somehow the image must be pushed away from the cornea. One way to do that is to employ an array of even smaller lenses placed on the surface of the contact lens. Arrays of such microlenses have been used in the past to focus lasers and, in photolithography, to draw patterns of light on a photoresist. On a contact lens, each pixel or small group of pixels would be assigned to a microlens placed between the eye and the pixels. Spacing a pixel and a microlens 360 micrometers apart would be enough to push back the virtual image and let the eye focus on it easily. To the wearer, the image would seem to hang in space about half a meter away, depending on the microlens.